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AMIC® Chondro-Gide® in the Knee

AMIC® Chondro-Gide® is a minimally invasive 1-step treatment that uses Autologous Matrix-Induced Chondrogenesis (AMIC®) combined with Chondro-Gide® to repair cartilage defects of all sizes. Backed by more than 10 years of clinical success, AMIC® Chondro-Gide® is an effective and cost-effective treatment1,2,3 for repairing damaged knee cartilage, alleviating or preventing pain, and slowing the progression of damage.

AMIC® Chondro-Gide®combines microfracturing (MFx) with the use of Chondro-Gide®, which covers and protects both the super clot resulting from MFx and the repair tissue. It can be performed either by mini-open or arthroscopic methods. Biocompatible and fully resorbable, Chondro-Gide® supports the body’s own healing potential.


With its specially designed bilayer structure, Chondro-Gide® provides a protective environment that fosters the growth of new tissue.5,6

  • Bio-derived, bilayer Collagen I/III membrane5
  • Biocompatible and naturally resorbed5
  • Easy to handle: supple and tear-resistant5
  • Can be glued into place5
  • Compatible with a range of tissue regeneration techniques7
  • One-step procedure5
  • Ready for use off the shelf5



Mini-Open Surgical Technique, Dr. M. Steinwachs


Arthroscopic Surgical Technique, Prof. Dr. Justus Gille


Surgical Videos


  1. SCHIAVONE PANNI, A., et al. Good clinical results with autologous matrix-induced chondrogenesis (Amic) technique in large knee chondral defects. Knee Surg Sports Traumatol Arthrosc, 2018 Apr 26(4):1130-36 (Clinical study)
  2. WALTHER, M., et al. Scaffold based reconstruction of focal full thickness talar cartilage defects. Clinical Research on Foot & Ankle, 2013, 1-5. (Clinical study)
  3. KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study)
  4. VOLZ, M., et al. A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. Int Orthop, Apr 2017, 41(4), 797-804. (Clinical study)
  5. Geistlich Pharma AG data on file (Bench test)
  6. GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
  7. KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006, 63(5), 616-626. (Clinical study)
  8. MITHOEFER, K., et al. The microfracture technique for the sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. Int Orthop, Apr 2017, 41(4), 797-804. (Clinical study)
  9. GOYAL, D., et al. Evidence-based status of microfracture technique: a systematic review of level I and II studies. Arthroscopy, Sep 2013, 29(9), 1579-1588. (Review of clinical studies)
  10. FONTANA, A., et al. Sustained five-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. Bone Joint J, May 2015, 97-B(5), 628-635. (Clinical study)
  11. GAO, L., et al. Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair.  Nature Scientif-ic Reports, 2017, 7:45189, DOI: 10.1038/srep45189 (Pre-clinical study)
  12. FRANK, R.M., et al., Failure of Bone Marrow Stimulation Techniques, Sports Med Arthrosc Rev, 2017, 25 (1) (Review of clinical studies)
  13. STEADMAN, J.R., Microfracture Technique for Full-Thickness Chondral Defects: Technique and Clinical Results. Operative Techniques in Orthopaedics. 1997. 7(4), 300-304. (Clinical study)
Dr. Sanja Saftic
International Product Manager