The best preventive measure against the development of CRBSIs is to observe strict hygiene guidelines when inserting and manipulating a CVAD. In addition to this, the instillation of antimicrobial solutions like Geistlich TauroSept® into the catheter lumen (antimicrobial lock) has been shown to be a clinically effective measure.1,2,3,4
Geistlich TauroSept® is intended for instillation in CVADs between treatments in order to prevent bacterial and fungal growth leading to microbial infection in the CVAD lumen as well as to maintain device patency and avoid staphylocoagulase-mediated coagulation.
The benefits of Geistlich TauroSept®:
- Broad antimicrobial, bactericidal and antifungal spectrum
- Prevention of biofilm formation
- No development of resistance associated with usage of Geistlich TauroSept®
- Favourable safety profile
- Johnston, D. A., G. Phillips, et al. (1993). Taurolin for the prevention of parenteral nutrition related infection: antimicrobial activity and long-term use. Clin Nutr 12(6): 365-8.
- Jurewitsch, B., T. Lee, et al. (1998). Taurolidine 2% as an antimicrobial lock solution for prevention of recurrent catheter-related bloodstream infections. JPEN J Parenter Enteral Nutr 22(4): 242–4.
- Mermel LA. (2001). New technologies to prevent intravascular catheter-related bloodstream infections. Emerg Infect Dis. Mar-Apr; 7(2): 197–9.
- Sherertz RJ, Boger MS, Collins CA, et al. (2006). Comparative in vitro efficacies of various catheter lock solutions. Antimicrob Agents Chemother. 50(5): 1865–8.