Treatment method AMIC®

Cartilage regeneration in only one surgical procedure

AMIC® - Autologous Matrix-Induced Chondrogenesis - is a surgical technique that has been developed based on the Microfracture-Technique for treatment of cartilage defects. It is a common procedure used to treat patients with large full thickness damage to the articular cartilage that goes all the way down to the bone.

AMIC® is an enhanced microfracturing technique where tiny fractures are created surgically in the bone. In the process stem cells are released from the bone marrow to form a so-called super-clot in the damaged cartilage area. The blood clot is covered and protected with Chondro-Gide®, a collagen membrane implant. This implant not only protects the cells, but also provides the cells with the proper stimulus to create cartilage repair tissue.

The main advantages of the AMIC® technique:


  • it is a one step procedure

  • larger defects which are not suitable for microfracture alone can be treated

  • it is a cost-effective treatment option which does not require a biopsy and cell cultivation in specialised laboratories

The AMIC® method has shown to be effective. Almost all of the patients who underwent this intervention reported that they were satisfied with the results. They all had the most severe form of chondromalcia or osteochondrosis dissecans. Radiographic imaging of the joint with MRI also showed that there was good regeneration of the cartilage, with the defects filled almost completely. Currently, therefore, AMIC® appears to be a good therapy option for severe chondromalacia and osteochondritis dissecans (OCD).

Whether AMIC® is suitable therapy option for you will be decided by your surgeon. This will depend upon age, nature and severity of lesion, level of activity and other medical factors.


Dr. Sanja Saftic
International Product Manager