Clinical Evidence - AMIC in the Hip
How Chondro-Gide Works®
Chondro-Gide® provides a protective cover and keeps in place cells released from the bone or introduced into a defect. It complements regenerative treatment approaches for chondral and osteochondral lesions. While enveloping the defect and the cells within it during the initial stages of the healing process, Chondro-Gide® resorbs over approximately 4 months1 and is replaced by native tissue.
Long-Term Advantages of AMIC® Chondro-Gide® vs. MFx Alone
The use of Chondro-Gide® in the hip is well established. Data up to 8 years post-op clearly demonstrates the long-term advantages of AMIC® Chondro-Gide® compared to MFx alone in acetabular defects2,3,4. In a study comparing arthroscopic MFx alone with AMIC® Chondro-Gide®, De Girolamo et al.3,5 investigated 109 patients. Patients with chondral defects in the hip that were associated with FAIs, were treated with AMIC Chondro-Gide® or MFx. There was no significant difference in age or the average defect size between the two patient groups.
AMIC® vs MACI®
A 5-year study by Mancini and Fontana compared the outcome of AMIC® Chondro-Gide® and matrix-induced autologous chondrocyte implantation (MACI) techniques for the treatment of medium sized acetabular chondral defects.5 AMIC offers additional benefits as a 1-step, minimally-invasive procedure that can reduce total treatment time and minimize morbidity.
For more details on Chondro-Gide®, surgical techniques, and clinical insights, download the brochure
- Chondro-Gide® IFU 2019, Geistlich Pharma AG
- FICKERT, S. et al., 2017, Biologic Reconstruction of Full Sized Cartilage Defects of the Hip: A Guideline from the DGOU Group “Clinical Tissue Regeneration” and the Hip Committee of the AGA. Zeitschrift für Orthop.die und Unfallchirurgie. 2017. Vol. 155, no. 06, p. 670-682. DOI 10.1055/s-0043-116218. Georg Thieme Verlag KG (Guideline).
- FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
- KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study).
- DE GIROLAMO, L., et al., 2018, Acetabular Chondral Lesions Associated With Femoroacetabular Impingement Treated by Autologous Matrix-Induced Chondrogenesis or Microfracture: A Comparative Study at 8-Year Follow-Up. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2018. Vol. 34, no. 11, p. 3012-3023. DOI 10.1016/j.arthro.2018.05.035. Elsevier BV (Clinical study).
- MANCINI, D., and FONTANA, A., 2014, Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement. International Orthopaedics. 2014. Vol. 38, no. 10, p. 2057-2064. DOI 10.1007/s00264-014-2403-1. Springer Science and Business Media LLC (Clinical study).