Autologous Chondrocyte Implantation (ACI) is a technique for the treatment of large isolated cartilage defects. A small sample of cartilage is harvested from a non-weight-bearing part of the joint during arthroscopy. In a laboratory the chondrocytes are dissolved away of the tissue composite and multiplied in culture dishes.

After a cultivation period of 3 to 4 weeks a cell count of approx. 1 million cells/cm² is achieved, depending on the size of the defect. In a second surgical procedure, the Chondro-Gide^® is inoculated with the cells and fitted into the defect. Under the physicochemical effects of the articular milieu, the cells, accompanied by a carefully-adapted rehabilitation programme, form high-grade regenerated cartilage, which has almost 90% of the biomechanical properties of healthy articular cartilage (Steinwachs, 2008).

Indications

• Chondral & osteochondral lesions grade III-IV (Outerbridge classification)
• Osteochondral defects in conjunction with bone-grafting
• Focal, traumatic defects
• Defect size 6.0 - 12.0 cm²
• Patients aged between 18 - 55 years

Advantages in the use of Chondro-Gide^® versus periosteum

• No need for a second operative site to remove periosteum
• Reduced risk of hypertrophy
• Reduced risk of delamination
• Shorter operative time
• Easy handling
• Consistent quality of matrix

Further information about Chondro-Gide^® and ACI is available from your Geistlich Surgery representative.