Orthoss®
As Close to Human Bone as Possible
The success of any regenerative orthopedic surgery depends largely on the quality and characteristics of the bone substitute used. For human bone to regenerate successfully, the bone substitute material should provide several conditions:
- A stable scaffold
- Rapid uptake of fluids
- A network of interconnected pores
- Suitable space for colonization.
Orthoss® is a bio-derived bone substitute made from highly purified bovine bone mineral. It is produced in Switzerland, following a rigorous quality assurance system to ensure its safety and quality.
Backed by nearly 25 years of clinical experience, Orthoss® offers the osteoconductive properties of human bone but is readily available for off-the-shelf use in convenient granule or block formats in a variety of sizes.1, 2
To see how Orthoss® provides all the conditions for successful bone regeneration, look at the illustrations below.
Orthoss® is very similar to human bone. Like human bone, it is highly porous and has a unique pore structure consisting of both nanopores and macropores.
The presence and interconnectivity of a large number of nanopores (10-20 nm) causes the high capillarity of Orthoss® and contributes to its high wettability.5 Embedded in the walls of the macropores, they enable Orthoss® to spontaneously take up and retain a large volume of blood and other fluids.
Macropores (100-300 μm) enable the movement and adhesion of bonebuilding cells throughout the Orthoss® scaffolding. They provide the space for blood vessels to grow into and for communities of cells to grow.5
Orthoss® provides a network of interconnected pores, which act as conduits for all the necessary elements for bone regrowth, such as blood.5 This network enables the rapid absorption of blood, promotes revitalization through new blood vessels, and enables the guided growth of new bone.
Immediately after the surgery, cells enter the interconnected network of pores, where they can attach, proliferate, and differentiate.6
After surgery, Orthoss® behaves very similarly to human bone as it becomes incorporated into the surrounding bone.7 Its exceptional osseointegration is due to its unique bimodal pore structure of nano- and macropores, which promotes healing by fostering the formation of new blood vessels and new bone tissue.
In the following months and years, the balance between the rate of resorption of the bone graft material and the rate of bone tissue formation is key. 8 Orthoss® resorbs slowly, providing a stable scaffolding that preserves the volume of the repaired area while the new bone tissue grows. The Orthoss® scaffolding stays in place until the new bone is ready to take its place. The outcome is a long-lasting repair that remains stable and strong over the long term.
References:
- Schlickewei, W. et al. (1991). Hefte zur Unfallheilkunde, 216: 59-69.
- Bereiter, H. et al. (1991). Hefte zur Unfallheilkunde, 216: 117-126.
- Thorwarth, M. et al. (2006). Oral Surg Oral Med Oral Radiol Endod. 101(3): 309-16.
- Jäger, M. et al. (2011). J. Orthop Res. 29(2): 173-80
- Data on file at Geistlich Pharma AG, Wolhusen, Switzerland.
- Kouroupis, D. et al. (2013). J Orthop Res. 31(12): 1950-8.
- Orsini, G. et al. (2005). J Biomed Mater Res B Appl Biomater. 74(1):448-57.
- Traini, T. et al. (2007). J Periodontol. 78(5): 955-61.
- Nandi, SK. et al. (2010). Indian J Med Res. 132:15-30.
- Kurien, T. et al. (2013). Bone Joint J. 95-B(5): 583-97.
- Reference list - Orthoss®
- Orthoss® - Die erste Wahl für Knochenregeneration
- Orthoss® - The Surgeon’s Choice for Bone Regeneration
- Orthoss® - Le choix du chirurgien pour la régénération osseuse
- Orthoss® - La scelta del chirurgo per la rigenerazione ossea
- Orthoss® - La elección del cirujano para la regeneración ósea
- Orthoss® - A escolha do cirurgião para a regeneração óssea