As Close to Human Bone as Possible

The success of any regenerative orthopedic surgery depends largely on the quality and characteristics of the bone substitute used. For human bone to regenerate successfully, the bone substitute material should provide several conditions:

  • A stable scaffold
  • Rapid uptake of fluids
  • A network of interconnected pores
  • Suitable space for colonization.

Orthoss® is a bio-derived bone substitute made from highly purified bovine bone mineral. It is produced in Switzerland, following a rigorous quality assurance system to ensure its safety and quality.

Backed by nearly 25 years of clinical experience, Orthoss® offers the osteoconductive properties of human bone but is readily available for off-the-shelf use in convenient granule or block formats in a variety of sizes.1, 2

To see how Orthoss® provides all the conditions for successful bone regeneration, look at the illustrations below.

"Orthoss® has a unique pore structure very similar to human bone, which provides the ideal conditions for bone regeneration."
Dr. Terance Hart, Root, Switzerland



  1. Schlickewei, W. et al. (1991). Hefte zur Unfallheilkunde, 216: 59-69.
  2. Bereiter, H. et al. (1991). Hefte zur Unfallheilkunde, 216: 117-126.
  3. Thorwarth, M. et al. (2006). Oral Surg Oral Med Oral Radiol Endod. 101(3): 309-16. 
  4. Jäger, M. et al. (2011). J. Orthop Res. 29(2): 173-80
  5. Data on file at Geistlich Pharma AG, Wolhusen, Switzerland.
  6. Kouroupis, D. et al. (2013). J Orthop Res. 31(12): 1950-8.
  7. Orsini, G. et al. (2005). J Biomed Mater Res B Appl Biomater. 74(1):448-57.
  8. Traini, T. et al. (2007). J Periodontol. 78(5): 955-61.
  9. Nandi, SK. et al. (2010). Indian J Med Res. 132:15-30.
  10. Kurien, T. et al. (2013). Bone Joint J. 95-B(5): 583-97.
Dr. Sanja Saftic
International Product Manager