The best prevention against the development of CRBSIs is observation of strict hygiene guidelines when inserting and manipulating a CVAD. In addition, the instillation of antimicrobial solutions like Geistlich TauroSept® into the device lumen (antimicrobial lock) has been shown to be clinically effective. (1, 2, 3, 4, 5)
Geistlich TauroSept® is intended for instillation in CVADs between treatments in order to lock the catheter, to prevent bacterial and fungal growth leading to microbial infection in the CVAD lumen as well as to maintain device patency by avoiding clotting of blood.
Overview of Geistlich TauroSept®:
- Broad bactericidal and fungicidal spectrum
- Prevention of biofilm formation
- No development of bacterial resistance
- Favourable safety profile
- Bisseling, T. M., M. C. Willems, et al. (2010). “Taurolidine lock is highly effective in preventing catheter-related bloodstream infections in patients on home parenteral nutrition: a heparin- controlled prospective trial.” Clin Nutr 29(4): 464–8.
- Jonkers, C., K. I. Looman, et al. (2012). “Incidence of central venous catheter related bloodstream infections in adults and children on home parenteral nutrition: heparin versus taurolidine catheter lock “ Clinical Nutrition Supplements 7(1): 203–204.
- Jurewitsch, B. and K. N. Jeejeebhoy (2005). “Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections.” Clin Nutr 24(3): 462–5.
- Olthof, E. D., M. W. Versleijen, et al. (2014). “Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions.” PLoS One 9 (11): e111216.
- Sherertz, R. J., M. S. Boger, et al. (2006). “Comparative in vitro efficacies of various catheter lock solutions.” Antimicrob Agents Chemother 50(5): 1865–8.