We use cookies to give you the best experience possible with our website and to improve our communication with you. We consider your selection and will only use the data you have approved us to gather.

These cookies help making a website usable by enabling basic functions like page navigation and access to secure areas of the website. The website cannot function properly without these cookies.

These cookies help website owners to understand how visitors interact with websites by collecting and reporting information anonymously. With this information we can constantly improve the experience we offer on our website.

These cookies are used to track visitors across websites. The intention is to display ads that are relevant and engaging for the individual user and thereby more valuable for publishers and third party advertisers.

Geistlich TauroSept®

CRBSIs (catheter-related bloodstream infections) continue to be associated with considerable morbidity and mortality and cause high treatment costs.

Optimal avoidance of infection and infection control are an absolute necessity when dealing with central vascular access devices (CVADs). Nevertheless, the incidence of CRBSI in Europe is 1.1 – 4.2 per 1000 catheter days despite the most varied preventive measures and the mortality of CRBSI is still between 5 and 25%.(1, 2, 3) The risk of CRBSI increases steadily depending on the duration of catheterisation. Already 24 hours after insertion of a CVAD, the vascular device can be coated with a biofilm. This typically consists of polysaccharides, fibrin, fibronectin or laminin and is formed by both microorganisms and endogenous substances.(4)

Microorganisms can reach the bloodstream via the outer surface of the CVAD or through the lumen; they lodge in the biofilm and are protected against immune mechanisms (phagocytosis, antibodies) and also partially against antibiotics. Gram-positive bacteria are responsible for about 50 – 70 % of CRBSI. In a European CRBSI prevalence study, gram-positive bacteria were detected in 71 %, gram-negative bacteria in 22 % and fungi in 7 %. The 5 most common microorganisms were coagulase-negative staphylococci, Staphylococcus aureus, Candida spp., Enterococcus spp. and Pseudomonas spp. (5)

References:

  1. Mermel, L. A. (2001). “New technologies to prevent intravascular catheter-related bloodstream
  2. infections.” Emerg Infect Dis 7(2): 197–9.
  3. Munoz, P., E. Bouza, et al. (2004). “Clinical-epidemiological characteristics and outcome
  4. of patients with catheter-related bloodstream infections in Europe (ESGNI-006 Study).” Clin Microbiol Infect 10(9): 843-5.
  5. Tacconelli, E., G. Smith, et al. (2009). “Epidemiology, medical outcomes and costs of catheter-
  6. related bloodstream infections in intensive care units of four European countries: literature- and registry-based estimates.” J Hosp Infect 72(2): 97–103.
  7. Donlan, R. M., Costerton J. W. (2002). “Biofilms: Survival mechanisms of clinically relevant
  8. microorganisms.” CMR.15.2.167–193.
  9. Bouza, E., R. San Juan, et al. (2004). “A European perspective on intravascular catheter-related
  10. infections: report on the microbiology workload, aetiology and antimicrobial susceptibility (ESGNI-005 Study).” Clin Microbiol Infect 10(9): 838–42.