Not all collagens are alike

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The human body sometimes needs help to regenerate bones, soft tissue or cartilage - help in the form of collagen materials. Collagen structures play an important part in the regeneration of body tissue. The collagen fibre composite is used by body cells as a guide rail for growth and a protective, supporting framework. It is often assumed that interaction between the cell surface and collagen structures also play a role in the differentiation of mesenchymal stem cells in bone or skin cells.

Collagen products, such as membranes or matrices, may be the key to controlling the body’s regeneration ability perfectly. With the right collagen framework, hypothetically every single body tissue can be regenerated.
Geistlich has the experts, the know-how and the technical equipment to design collagen fibers and collagen scaffolds for different therapeutic needs.


Collagen – the all-rounder

Collagen is so special because it is naturally occurring, it is an all-natural material. Over million of years, it has evolved a high safety level which is one of the key issues nowadays. In fact, there are more than 30 different types of collagen in the different parts of the body. For example, collagen I is the most important protein in bone matrix. If collagen synthesis is genetically impaired, patients can suffer from brittle bone disease.

“For a periodontist collagen is essential. Collagen structures are the backbone of the periodontal attachment.”
PD Dr. Stefan Fickl

 

An analogy to clothes

Safety and performance are dependent on the structure and nature of the collagen. But how can the function of collagen been described? Perhaps like this: There are hundreds of types of clothes. There are cotton clothes, silk clothes, knitted clothes; there are scratchy clothes, soft clothes, clothes made of anti-allergenic fabrics etc. And in the same way, there are many types of collagen. And so, just like we do not like to have scratchy materials on our skin, certain cells, for instance, prefer very particular types of collagen on which they feel good and subsequently establish themselves. Other types of collagen are less inviting for colonisation by cells, but have other important functions instead: They separate different tissues from one another. Or ensure that a tissue like bone is elastic, rather than brittle. Geistlich has the experts, the know-how and the technical equipment to design collagen fibers and collagen scaffolds for different therapeutic needs.