Autologous Chondrocyte Implantation (ACI) is a technique for the treatment of large isolated cartilage defects. A small sample of cartilage is harvested from a non-weight-bearing part of the joint during arthroscopy. In a laboratory the chondrocytes are dissolved away of the tissue composite and multiplied in culture dishes.
After a cultivation period of 3 to 4 weeks a cell count of approx. 1 million cells/cm2 is achieved, depending on the size of the defect. In a second surgical procedure, the Chondro-Gide® is inoculated with the cells and fitted into the defect. Under the physicochemical effects of the articular milieu, the cells, accompanied by a carefully-adapted rehabilitation programme, form high-grade regenerated cartilage, which has almost 90% of the biomechanical properties of healthy articular cartilage (Steinwachs, 2008).
- Chondral & osteochondral lesions grade III-IV (Outerbridge classification)
- Osteochondral defects in conjunction with bone-grafting
- Focal, traumatic defects
- Defect size 6.0 - 12.0 cm2
- Patients aged between 18 - 55 years
Advantages in the use of Chondro-Gide® versus periosteum
- No need for a second operative site to remove periosteum
- Reduced risk of hypertrophy
- Reduced risk of delamination
- Shorter operative time
- Easy handling
- Consistent quality of matrix